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Fentanyl Powder (also known as fentanil) with a rapid onset and short
duration of action. It is a strong agonist at the μ-opioid receptors.
Fentanyl is estimated to be between 50 and 100 times as potent as
morphine. Fentanyl Powder was first made by Paul Janssen in
1960,following the medical inception of pethidine (also known as
meperidine, marketed as Demerol) several years earlier. Janssen
developed fentanyl by assaying analogues of the structurally related
drug pethidine for opioid activity. The widespread use of fentanyl
triggered the production of fentanyl citrate (the salt formed by
combining fentanyl and citric acid in a 1:1 stoichiometry), which
entered medical use as a general anaesthetic under the trade name
Sublimaze in the 1960s. Following this, many other fentanyl analogues
were developed and introduced into medical practice, including
sufentanil, alfentanil, remifentanil, and lofentanil.
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